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WP29

Protocol-Guided Autonomous Research with Claude Code

Scientific Verification, Reproducibility, and the Cost of Delegation: A Controlled Study

Simon-Pierre Boucher · Cahiers de recherche UQO · octobre 2026 · v1.0

Instruction files that steer coding agents through research tasks range from one sentence to several thousand words of phases, gates and integrity rules, but whether that structure changes what the agent delivers has not been measured with the agent held fixed. The paper reports 288 live Claude Code runs (362…